Journal Watch: MHC and intracellular self

Shiv Prasad shiv at scrapie.med.umn.edu
Wed Aug 19 15:19:32 EST 1992


In article <92232.101920FORSDYKE at QUCDN.QueensU.CA> <FORSDYKE at QUCDN.QueensU.CA> writes:
>
>  Forsdyke: Yes, synthesis and degradation (turnover).  OK. Now be patient and
>            tell me what determines rates of synthesis and degradation.
>
Ok, rates of transcription and translation determine synthesis (I hope we're
not going to get into promoters and enhancers).  As far as degredation, protein
stability, i.e. maintaining it's conformation, is certainly a factor, as de-
natured proteins may be degraded, but I'm not really sure what controls the 
half-lives of proteins.  I'm not exactly sure where you're going with this.
Are you going to suggest that viral proteins have longer half-lives, which may
lead to higher relative concentrations in the cell?
>
>  Forsdyke: OK. Let's just take a "generic" virus which goes about its
>            business within the cell and eventually lyses the cell.
>            It will make some viral proteins more than others, but a minimum
>            of one protein would be     necessary in order to get a foreign
>            peptide displayed at the cell surface with MHC class I.
>

So back to the original question, what is the system that prevents all of
the cellular self-proteins from competing with the viral non-self protein.

>>>References:   Forsdyke, D. (1992) Bionet.immunology 812 947edt
>>>              Prasad, S. (1992) Bionet.immunology 814 1516gmt
>>>              Forsdyke, D. (1992) Bionet.immunology 817 1757edt
>>>              Prasad, S. (1992) Bionet.immunology 818 133gmt
>>               Forsdyke, D. (1992) Bionet.immunology 818, 1616edt
>                Prasad, S. (1992) Bionet.immunology 819, 405gmt


P.S.  How are we doing on the citation indices :-).



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