Journal Watch: MHC and intracellular self

George W Chacko gchacko at magnus.acs.ohio-state.edu
Mon Aug 17 20:58:45 EST 1992


In article <1992Aug18.013306.4745 at news2.cis.umn.edu> shiv at tsp.med.umn.edu (Shiv Prasad) writes:

>In your experiment it would seem that whichever protein aggregates first
>would depend on the initial concentration of each protein, and the homotypic
>affinities.  

I'm not sure what 'homotypic affinities' means but if it indicates the
affinity of a protein molecule for another molecule of the same
protein which can also be expressed in terms of concentration, e.g.

A + A  <-> 2A  => Keq = [2A]/{[A]*[A]}

then the first protein to aggregate would be the one with the highest
homotypic affinity as defined above. That of course, is dictated
principally by its primary amino acid sequence as well as standard 'other
factors' like pH and ionic strength. Right?

George



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