Self/Not-self Discrimination: the basics
pkemp at byron.u.washington.edu
Thu Jul 23 20:07:02 EST 1992
In article <92202.171601FORSDYKE at QUCDN.QueensU.CA> <FORSDYKE at QUCDN.QueensU.CA> writes:
>Question raised in my original posting:
>>> (ii) List possible mechanisms of self discrimination WITHIN
>>> organisms. (The latter may be subdivided into EXTRACELLULAR
>>> self/not-self discrimination, which is what most immunologists
>>> are familiar with, and INTRACELLULAR self/not-self discrimina-
>>> tion, which is more controversial.)
> Shiv Prasad responds to my request for a list of possible mechanisms of
>self/not-self discrimination with a list of systems and much head scratching.
> (i) an experimental autoimmune system (uveoretinitis).
> (ii) aggregation of red and green sponges, like with like.
> (iii) bacterial restriction enzymes.
> (iv) transgene expression in the pancreas.
>One approach is to extract from these (and other) systems, some common
>elements. A good starting point would be (iii) on the grounds of
>simplicity, ...then (ii). With the resulting answers, we might be in
>a better position to ponder (i) and devise experiments using techniques
>similar to those in (iv).
> Anyone care to set the ball rolling?
Yes, go out and get the book _The Evolution of Individuality_ by Leo Buss.
It's a great book, and a must read for thinkers in this field.
> Don Forsdyke. Discussion Leader
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