Generating somatic diversity

Jesse M. Goldman your-email-addr at a1.mscf.upenn.edu
Wed Oct 14 13:57:29 EST 1992


We know that point mutations are introduced into the variable regions
of immunoglobin genes when rechallenged with antigen and b cells are
selected which have higher affinity than the "mother" B-cell.  I know this
probably happens in germinal centers and that b-cells producing either
self directed immunoglobin or ineffective antibodies are delected.
But does anyone have ideas on how genes produce rapid rates of mutation?
And especially involving only variable regions?



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