INTERFERON TAU

GORDON BETTS JB5369 at ETSUACAD.ETSU.EDU
Thu Dec 2 11:13:38 EST 1993


IN A RECENT NOTE, HORST IBELGAUFTS WRITES:
Dear netters,
what is interferon tau? can anyone also provide me with a suitable
reference?
thanks a lot.

IN REPLY:
INTERFERON TAU IS STRUCTURALLY SIMILAR TO IFN'S ALPHA AND BETA WITH SIMILAR
FUNCTIONS.  IT IS PRODUCED BY THE EMBRYONIC TROPHOBLAST OF COWS, SHEEP AN GOATS
AT ABOUT DAY 11 OF PREGNANCY (DEPENDING ON THE EXACT SPECIES).  IT INHIBITS
PROSTAGLANDIN F2 ALPHA PRODUCTION WHICH WOULD OTHERWISE CAUSE REGRESSION OF THE
CORPUS LUTEUM AND THE CONSEQUENT NEXT ESTROUS CYCLE WOULD ENSUE.  THUS IT IS
THE PROTEIN RESPONSIBLE FOR MATERNAL RECOGNITION OF PREGNANCY IN THESE SPECIES.
IT WAS ORIGINALLY NAME BOVINE (OR OVINE OR CAPRINE) TROPHOBLAST PROTEIN-1 TO
SIGNIFY IT AS THE FIRST MAJOR PROTEIN PRODUCED BY THE TROPHOBLAST.  GOOD REFERE
NCES TO SEARCH WOULD BE PAPERS BY P.J. HANSEN, R.M. ROBERTS OR F.W. BAZER.
BAZER AND ROBERTS WERE RESPONSIBLE FOR THE EARLY DISCOVERY OF THIS IFN.

Distrust Simplicity.                   Simplify, simplify.
  Alfred North Whitehead                 Henry David Thoreau
==================================================================
J. Gordon Betts
East Texas State University
Dept. of Biological Sciences
Commerce, TX 75429-3011
JB5369 at ETSUACAD.ETSU.EDU



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