Athymic Nude Mice

Paul N Hengen pnh at
Wed Feb 24 13:18:35 EST 1993

I'm not an immunologist, so here goes a naive question:

Athymic nude mice are nu/nu ie. they are homozygous
for the nu (nude) recessive gene. What is the genetic
basis for their athymic condition? Are the nu gene and
developmental genes of thymus genetically linked, or
is there some reason why they would be the same gene? 
Can someone support their answer with references?

Thank You.

Paul N. Hengen
National Cancer Institute
Frederick Cancer Research and Development Center
Frederick, Maryland 21702-1201 USA

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