Tolerance

Jerry Woodward woodward at seqanal.mi.uky.edu
Fri Jul 16 13:09:52 EST 1993


Actually, the mice were born viable so TGF-beta production by the embryo must
not be a requirement.  My question with regards to fetal recognition, is, is
it tolerance or sequestration?  Don't pregnant mothers respond normally to
the relevant alloantigens in vitro and by skin graft rejection?  
We have a transgenic mouse model in which allo class I is expressed
in the lens of the eye and nowhere else.  In this case, there appears
to be no tolerance, but no recognition either, presumably due to the 
sequestered nature of the lens.



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