immunogenic proteins

Chris Upton cup at bones.biochem.ualberta.ca
Wed Jul 21 09:45:38 EST 1993


Hi,
   I understand that peptides are usually conjugated to KLH or BSA to raise
antibodies, but is there anything special about these proteins that helps
to produce a good immune response? Are they acting at all like a protein
adjuvant? And if not, are there any proteins that might? The idea being to
express a protein from a virus in vivo and to try and get a good immune
response to something that normally gives a poor one, by fusing 2 genes.
I suppose I could try a viral membrane protein that's known to give good
antibodies, but I'd rather use something from an unrelated system.
Any ideas appreciated!

Chris Upton
University of Alberta

As of Sept 1st 1993,  cupton at sol.uvic.ca
Department of Biochemistry & Microbiology
University of Victoria         
PO BOX 3055, Victoria          
BC V8W 3P6                     
Canada                 
(604)721-6507 phone        
(604)721-8855 fax



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