Thomas B. Kepler
kepler at stat.ncsu.edu
Fri Mar 5 11:50:49 EST 1993
In article <1993Mar4.173539.6783 at news.stolaf.edu>, bell at mari.acc-admin.stolaf.edu (David E Bell) writes:
|> The problem:
|> Especially in LE all people are speaking of ab against dna. But dna is normally
|> inside the cell and not presented on the surface ! ...
Furthermore, DNA is not a polypeptide and so there is no reason to believe that it
can be presented to T cells, even though the anti-DNA response is T dependent.
Some clues may be found in Diamond et al. (1992) Ann. Rev. Immunol. 10:731-57, in
which they write, e.g., "The association of anti-dsDNA antibodies with renal disease
may merely reflect their reactivity with poly-anionic molecules in the basement membrane
of the glomeruli..."
Any other ideas out there?
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