David E Bell
bell at mari.acc-admin.stolaf.edu
Thu Mar 4 12:35:39 EST 1993
Last month I spent lots of hours thinking about autoimmune diseases and
there's one fact I really can't understand ! Many, especially older, books
explain autoimmunity with reacting antibodies against self-epitopes.
There are good examples of diseases were antibodies may play the main role. Thisis for instance thyreoditis and LE.
Especially in LE all people are speaking of ab against dna. But dna is normally
inside the cell and not presented on the surface ! Normally I would think
antibodies can't do anything against intracellular epitopes, but nobody is
I think in a process of inflammation ab's could enhance the situation by
accumulating at sites were cells have been already destroyed. But how can
an ab against dna kill a healthy cell ??
Maybe anybody could give me some ideas of the role of anti intracellular
antibodies in autoimmune disease...
Thanks a lot for any reply !!
University of Aberdeen / Immunology
e-mail: ugn4501 at aberdeen.ac.uk
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