Naive Q about Killer T activation

Stas Philippe philstas at is1.vub.ac.be
Thu May 6 07:40:15 EST 1993


In article <borbor-060593100745 at 129.194.82.105> borbor at divsun.unige.ch (Boris Borcic) writes:
>I bought two immunology books
>CD8 T Cells are activated by CD4 Cells,
>monocytes, or perhaps directly.
>Somewhere I found written that T Cells
The control of CD*+ Cytotoxic cells by T-helper cells (cd4+) is a
mojor question in immunology. A class-I, TcR interaction is necessary,
but I thought a class II inteaction could nt be blocked without 
activity. The presentce of Th2 cells is a necessity.
>do not show HLA II antigens until they
>are activated, which seems to exclude
>an activation path for CD8 T Cells 
>similar to that of B cells, but since
>most CD8 aren't also CD4, an activation
>path like that of CD4s by monocytes
>leading to B cell response seems
>also excluded.
>
The possibility that the cd8 cell has to be activated by an Class I cells
could be the first step. An aditional activation could be the second step, by the suddenly arrising Class II molecules on the CD8+ cells.

Could someone please correct me if I'm wrong?


Johor

/*-- The World is Just a Huge Fractal --*/
float o=0.075,h=1.5,T,r,O,l,I;int _,L=80,s=3200;main(){for(;s%L||
(h-=o,T= -2),s;4 -(r=O*O)<(l=I*I)|++ _==L&&write(1,(--s%L?_<L?--_
%6:6:7)+"World! \n",1)&&(O=I=l=_=r=0,T+=o /2))O=I*2*O+h,I=l+T-r;}
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-  Philippe Stas                        philstas at vub.ac.be  -
-  Dept. of Cellular Immunology                             -
-  Free University of Brussels          tel: 32-2-359.03.58 -
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