GORDON CONFERENCE ANNOUNCEMENT

Matthew Temple -- 432-7696 MANAGER at RASCAL.MED.HARVARD.EDU
Thu May 13 13:05:00 EST 1993



		    GORDON CONFERENCE ANNOUNCEMENT


Some places are available for the GORDON RESEARCH CONFERENCE on
NEUROIMMUNOLOGY, to be held this coming June 13-18, at Colby-Sawyer College
in New Hampshire.  Financial assistance is available for applicants who may
need it.  Contact Dr. Lois Lampson (lampson at cnd.bwh.harvard.edu; phone
617-732-7015; FAX 617-732-7787) or the Gordon Conference organization
(BCP101 at URIACC; phone 401-783-4011; FAX 401-783-7644). Program:   

GORDON RESEARCH CONFERENCES
---------------------------
BIOLOGY OF THE IMMUNE RESPONSE TO ANTIGEN WITHIN THE CNS
June 14-18, 1993 
Colby-Sawyer College, New Hampshire
Lois A. Lampson, Chair

Monday a.m.:  REGULATION OF THE MAJOR HISTOCOMPATIBILITY COMPLEX WITHIN THE CNS	
-------------------------------------------------------------------------------
W. Armstrong:  	"Current MHC overview:  Distribution, regulation, MHC-antigen
                 complexing."                                   
K. Ozato:       "Molecular biology of MHC class I regulation:  Special CNS
                 mechanisms?"                          
J. Ting:        "MHC class II regulation:  Special CNS mechanisms?"  
E. Cowan: 	"When is MHC up-regulation seen in the CNS?  What functions are
                 served?"

Monday p.m.:  PHARMACOLOGIC CONTROL OF THE IMMUNE RESPONSE TO ANTIGEN WITHIN THE
              CNS
--------------------------------------------------------------------------------
B. Arnason:     "The universe of regulatory molecules:  Effects of
                "neurotransmitters" on 	lymphocytes; of "lymphokines" 
                 on neural cells." 			
E. Frohman:     "Immuno-regulatory molecules produced within the CNS itself."
F. Lublin:      "Regulation in vivo:  Cytokine with opposing effects on
                 different cells."

Tuesday a.m.: CONTROL OF LEUKOCYTE ENTRY AND MIGRATION WITHIN THE BRAIN 
-----------------------------------------------------------------------
R. Melder: 	"The biophysics of leukocyte circulation:  How much can it
                 explain?" 
D. Male: 	"Signals and adhesion molecules at the cell/brain interface:
                 Unique to brain?"  
A. Vortmeyer	"Independent control of leukocyte entry and migration through   
                 the brain."
  
Tuesday p.m.: IMMUNE EFFECTOR MECHANISMS THAT ARE ACTIVE IN THE CNS
-------------------------------------------------------------------
J. Sedgwick:    "Antigen presentation and MHC-restricted T cell functions within
                 the CNS."
J. Antel:       "The range of cell-mediated effector functions:  Are any unique
                 to the CNS?"
W. Hickey:      "Other" cells in the CNS:  When do they enter and leave? What
                 do they do?"

Wednesday a.m.: HOW CNS TUMOR AND VIRUSES REGULATE THEIR IMMUNE ENVIRONMENT
---------------------------------------------------------------------------
M. Kuppner: 	"How brain tumors affect their immune environment".  
L. Mucke:	"How viruses change their immune environment."  
C. Petito:      "AIDS-associated changes that can facilitate opportunistic CNS
                 infection."

Wednesday p.m.: BENEFICIAL IMMUNE RESPONSES AGAINST TUMOR AND VIRUS WIHTIN THE
               CNS
------------------------------------------------------------------------------
L. Lampson:     "Anatomy of CNS immuno-regulation:  Importance of site within
                 the brain, site within the tumor, site of antigen within the
                 cell."
P. Doherty:     "Effector mechanisms and target cells in CNS viral infections."

Thursday a.m.: DELETERIOUS IMMUNE RESPONSES TO ANTIGEN WITHIN THE CNS
---------------------------------------------------------------------
M.K. Nicholas:	"Effector mechanisms in CNS graft rejection: Unique to the CNS?"
R. Sobel:       "Effector mechanisms in CNS autoimmunity:  Unique to the CNS?"  
J. Posner: 	"Paraneoplastic syndromes: Potential effector mechanisms." 
R. Hohlfeld: 	"Muscle immunobiology:  How does it compare to that of the CNS?"

Thursday p.m.: EQUIVOCAL AND SECONDARY IMMUNE RESPONSES IN THE CNS
------------------------------------------------------------------
P. McGeer: 	"MHC upregulation and other signs of immune activation in
               	"nonimmunologic" disorders:  What do they imply?"   

Friday a.m.:   SYNTHESIS:  GENERAL DISCUSSION AND REMARKS BY SELECTED
               PARTICIPANTS
---------------------------------------------------------------------
What is unique about the immune response to antigen within the CNS?   
Beneficial and deleterious CNS immune responses:  Two sides of
               the same coin.

_____________________________________________________________________________

Poster sessions. Please submit a brief poster abstract (<250 words) with
application.  Some abstracts may be selected for oral presentation.  
Obtain application from:  

     Gordon Research Conferences/Neuroimmunology Conference
     Gordon Research Center
     University of Rhode Island
     Kingston RI    02881-0801
     Phone (401)783-4011; FAX (401)783-7644

or from: 

     Dr. Lois Lampson, Dept. of Neurology
     LMRC 116, Brigham and Women's Hospital,
     Boston MA 02115
     Phone (617)732-7015; FAX (617)732-7787.




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