Inhibiting phagocytosis

Dean Hewish deanh at
Tue Aug 2 20:56:59 EST 1994

My wife needs to distinguish active phagocytosis from passive
absorbance in human peripheral blood macrophages. She wants to inhibit
phagocytosis in her controls. Cytochalasin-b has been reported to be an
inhibitor of phagocytosis but it doesn't work to 100% in her system (
the cells still take up the particles). Does anyone know if there are
any tricks to using cytochalasin-b and if there are any other agents
that can be used to inhibit phagocytosis?

Dean R. Hewish
Cell biologist and Flow Cytometrist
CSIRO Division of Biomolecular Engineering
Parkville, Victoria, Australia

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