Self/nonself discrimination

Dr M.R. Clark mrc7 at cus.cam.ac.uk
Mon Aug 8 11:36:26 EST 1994


In article <94211.144113FORSDYKE at QUCDN.QueensU.CA>,
 <FORSDYKE at QUCDN.QueensU.CA> wrote:
>In article <31bhe8$3f1 at agate.berkeley.edu>, frauwirt at mendel.Berkeley.EDU (Ken
>Frauwirth (BioKen)) says:
>
>>How could a cell recognize a "non-self" antigen (e.g. viral protein) that
>>was synthesized by its own ribosomes?
>
>     It is proposed that over evolutionary time cells have fine-tuned self
>protein concentrations to the concentrations of the other self proteins with
>which they are moving through time. The cytosol is so crowded that each

I cannot accept this argument about concentration because it assumes that there is no genetically or enviromentally determined differences between diverse 
individuals which can still lead to tolerance.

Any reasonable hypothesis for tolerance must allow the system to operate without
prior knowledge of what self is genetically! Most of us are after all outbred!




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