Self/nonself discrimination

Sun Aug 14 07:49:39 EST 1994

In article <32f0j3$cg3 at>, frauwirt at mendel.Berkeley.EDU (Ken
Frauwirth (BioKen)) says:

>presented on Class I MHC (and research supports the idea that the protein
>is expressed at a low level, so aggregation is likely not a factor).

        No, this does not follow. Based on its intrinsic solubility a
protein will tend to aggregate at a particular concentration, which may be
quite low relative to other more abundant proteins. In the crowded cytosol
the "pressure" from the other proteins will tend to lower the aggregation
threshold. Thus all proteins are interacting to varying extents. Based on
factors such as rates of transcription, mRNA stability, etc. there is the
possibility that, over evolutionary time, each gene fine-tunes its protein
concentration to the other proteins with which it has been travelling through
time.  This may partly help York in some of the problems he was having.

                        Sincerely,  Don Forsdyke
                                    Discussion Leader. Bionet.immunology

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