Self/Not-self discrimination (YORK)

Thu Aug 18 07:57:18 EST 1994

In article <32ttqj$13o at>, gappleya at (Greg
Appleyard) says:
>My question is, since T-cells do the self/non-self discrimination and
>such discrimination is made vigilent against intracellular infections
>through thymic education, how is it that self-specific T-cells exist
>normally in the periphery without rampant autoimmunity. The self-specific
>T-cells must be regulated, but how? It seems a paradox that self/non-self
>discrimination is made on the basis of selecting T-cells without
>self-reactivity (negative selection) and yet self-specific T-cells are
>part of the normal lymphocyte repertoire.

      No paradox. Self-specific T-cells are part of the normal lymphocyte
      repertoire because peptides from the corresponding intracellular self
      proteins have not been presented in order to cause the deletion of the
      self-specific T-cell clones. This is because there is an intracellular
      mechanism  for distinguishing self/not self. This mechanism is very
      "primitive" in that it evolved before multicellular organisms evolved.
      (J.Th.Biol. 167,7-12; J. Biol.Sys.2, in press). Some self peptides are
      presented, and in these cases T cell deletion has occurred.

                      Sincerely, Don Forsdyke Discussion Leader

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