In article <3cl33l$nm0 at tali.hsc.colorado.edu> bb465 at freenet.HSC.Colorado.EDU (Jonathan Grynspan) writes:
>>i am looking for info concerning t cell activation specifically
>regarding tyrosine kinases activated intracellularly as well as
>the mechanisms known for enhancing transcription following activation
>is there data about upregulation of any gene
>additionally i vaguely recall something about a cd28r product
>increasing rna stability whose doing this work i
>would appreciate references
You recall correctly.
Stimulation through CD28 results in increased IL-2 message stability.
There are several papers on this from Craig Thompson's lab. If you
Email me your snail mail address I can get some reprints to you (I'm
a post-doc in the lab, although I have nothing to do with this project).
I forget what other messages get stabilized, but there are some. There
are a million different projects going on in the lab, and to be honest,
this isn't one of my favorites (interest-wise) so I don't keep up with it
as well as I should!
>bb465 at colorado.edu>regards