Complement Concentrations

Michael Doerrschuck bzbdoerr at avemaria
Sat Dec 17 14:38:38 EST 1994


In article <3cn8l7$2bl at post.its.mcw.edu> skonings at post.its.mcw.edu (Steve Konings) writes:
 > Michael Doerrschuck (bzbdoerr at avemaria) wrote:
 >
 > : I wonder whether anyone has a good and up to date 
 > : reference to normal ranges for the concentration
 > : of C3-Complement and C4-Complement in human peripheral 
 > : blood serum.
 >
 >
 >  I have a source that gives the following ranges for normal values:
 >
 >	   C3:	70-150 mg/dL
 >	   C4:	12-38 mg/dL
 >

Thank you very much for the information. May I ask you to post the 
reference to your source for the values? 

Now, I have the following data, and it does not seem to be very 
consistent among itself to me:


                              C3               C4
                            [mg/dl]          [mg/dl]


     Lab I                 56 - 120          21 - 49
     Lab II (Jan 94)       80 - 140          20 - 50
     Lab II (May 94)       50 -  90          10 - 40
     Steve's Source        70 - 150          12 - 38
 
     Source A                130               50

(Source A:  Friemel, Brock: Grundlagen der Immunologie, 
Berlin, 1990 )


Does anyone have any idea why the values are so diverse? 

Does anyone know the statistical distribution of the Complement 
Concentration among the population? I would tend to think, that 
neither C3 nor C4 does follow a symmetrical distribution function. 

Does anyone know a study explicitely devoted to this topic?

Again, thank you very much!


Michael


--
Michael Doerrschuck

Konrad-Zuse-Zentrum fuer Informationstechnik Berlin 
Heilbronner Strasse 10
10711 Berlin-Wilmersdorf
Germany

E-Mail:  Doerrschuck at sc.ZIB-Berlin.DE
Telefon: +49-30-89604-268



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