HIV infection of Chimps

Naomi Gayle Housman nhousma at EMORYU1.CC.EMORY.EDU
Thu Dec 29 22:05:13 EST 1994


Dear Shahram:

Thanx for the reply!!  Yeah, I knew that was the question of the year 
when I wrote it.  However, I don't think that this question does not have 
any leads (not that you suggested that it didn't either).  I was thinking 
and wondering if there are evolutionary consequences for HIV-1 
pathogenesis in terms of its ability to cause disease in other non-human 
primates.  In other words, if HIV-1 evolved within humans for some time 
(how long I will not speculate, although I would agree with the good 
doctor Paul Ewald that HIV-1 has probably been around for quite some time 
roaiming in some remote African population we have yet to discover) than 
are there consequences resulting from host-parasite relationships 
(hiv-1-human in this case) that manifest in terms of virulence and 
pathogenicity???  

Currently, we are beginning to design a set of experiments to address the 
issue of host specificities and resistance to infection (in vitro as well 
as in vivo).  I was also wondering if anyone has looked at the 
development of HIV-1 quasispecies in HIV-1 infected chmips?  Do you know 
of any study published or non-published that addressed genetic variation 
of HIV-1 in chimps in vivo?? 

Anyway thanx for your response and I hope to hear from you soon....





On 30 Dec 1994, Shahram Mori wrote:

> Janet Cox (janet at KB.USM.MY) wrote:
> : I wonder how controlled the living conditions of these experimental 
> : chimps is? Are they fed an optimum diet? Are they regularly seen by a vet. 
> : I assume the answers to these questions has to be yes. I then wonder how 
> : does the living environment and exposure to opportune pathogens of these 
> : chimps relate to that of people exposed to or infected with HIV? However 
> : cruel it may seem I think the living conditions,diet, environment etc. of 
> : the chimps should simulate that of the people at risk and 
> : then expose the chimps to HIV to see if the symptoms associatedwith AIDs 
> : develop. This experiment if not already done (appologies if this strategy 
> : has been adopted with the chimp exps) may help address the question 
> : of co-factors. It could 
> : however be that the chimp lymphocytes while infected still function. I 
> : expect that this exp. has been carried out. Just some thoughts - did you 
> : get much feed back to this question- I hope so? Regards, Janet.  
> Janet,
> At primate research Lab ( white sands research center) here in New Mexico,
> The primates do NOT live in sterile conditions. They are in contact with
> the Vets and other general care people, whom are the best resevoir for 
> transfer of opportunistic infections. Remember we do not see a decrease in
> T-cell counts in Chimpanzees.
> 
> 
> : On 17 Dec 1994, Naomi Gayle Housman wrote:
> 
> : > 
> : > I have been doing some preliminary reading on HIV-1 infection of 
> : > Chimpanzees.  I was wondering if anyone has any insight into why 
> : > chimpanzees don't develop AIDS after infection with HIV-1, despite the 
> : > relatively high viral burden in lymph nodes and PBL???
> : > 
> : > 
> : > nhousma at unix.cc.emory.edu
> Naomi,
> This is the 100 000 000... question. You find the answer to this you'll win
> a noble prize in medicine. I am working on this. :)
> Cheers,
> 
> --
> Shahram Mori					   _/\_
> Program in Molecular Biology			  _\  /_
> Dept. of chemistry and Biochemistry Box 3C	  \_  _/
> NMSU  Las Cruces NM				    ||
> 88003
> 
> 
> 
> 



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