HIV infection of Chimps

Shahram Mori smori at nmsu.edu
Thu Dec 29 19:20:43 EST 1994


Janet Cox (janet at KB.USM.MY) wrote:
: I wonder how controlled the living conditions of these experimental 
: chimps is? Are they fed an optimum diet? Are they regularly seen by a vet. 
: I assume the answers to these questions has to be yes. I then wonder how 
: does the living environment and exposure to opportune pathogens of these 
: chimps relate to that of people exposed to or infected with HIV? However 
: cruel it may seem I think the living conditions,diet, environment etc. of 
: the chimps should simulate that of the people at risk and 
: then expose the chimps to HIV to see if the symptoms associatedwith AIDs 
: develop. This experiment if not already done (appologies if this strategy 
: has been adopted with the chimp exps) may help address the question 
: of co-factors. It could 
: however be that the chimp lymphocytes while infected still function. I 
: expect that this exp. has been carried out. Just some thoughts - did you 
: get much feed back to this question- I hope so? Regards, Janet.  
Janet,
At primate research Lab ( white sands research center) here in New Mexico,
The primates do NOT live in sterile conditions. They are in contact with
the Vets and other general care people, whom are the best resevoir for 
transfer of opportunistic infections. Remember we do not see a decrease in
T-cell counts in Chimpanzees.


: On 17 Dec 1994, Naomi Gayle Housman wrote:

: > 
: > I have been doing some preliminary reading on HIV-1 infection of 
: > Chimpanzees.  I was wondering if anyone has any insight into why 
: > chimpanzees don't develop AIDS after infection with HIV-1, despite the 
: > relatively high viral burden in lymph nodes and PBL???
: > 
: > 
: > nhousma at unix.cc.emory.edu
Naomi,
This is the 100 000 000... question. You find the answer to this you'll win
a noble prize in medicine. I am working on this. :)
Cheers,

--
Shahram Mori					   _/\_
Program in Molecular Biology			  _\  /_
Dept. of chemistry and Biochemistry Box 3C	  \_  _/
NMSU  Las Cruces NM				    ||
88003





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