re immunol. of B7-1 and B7-2

Paul J Travers p_travers at
Wed Feb 2 10:03:18 EST 1994

Does anyone know anything about the relative binding of B7-1 and B7-2 to
CD28 vs CTLA-4?  Or is the fact that we have two ligands for two receptors,
one of each pair being induced after activation, mere coincidence?

On a more pedantic note, does anyone worry that there is already a murine
cell surface marker B7(2), related (I think) to HSA?


Paul J Travers                          phone : +44-(0)71-631-6262 (office)
ICRF Structural Biology Unit             "       "       "    6268 (lab)
Birkbeck College                          fax : +44-(0)71-436-8918
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London WC1E 7HX                         email :  p_travers at
England                                    or :  paul at

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