Tue Feb 1 18:07:40 EST 1994

In <2ik4gp$959 at> trenno at writes:

> Where I differ is the conclusion that destroying the large fish removes
> them (the Fishus largus species, not those particular fish that happened to
> get caught) from the avilable pool. I contend that the extent to which the
> pool of fish is affected depends pretty much on how long after having used
> the first net you decide to go fishing again.  As long the large fish were
> allowed to breed before they were removed, you will have more of them,
> provided you wait long enough.

I'd like to add a (probably) more controversial point here, which I don't
necessarily advocate.  Another type of negative selection in T cells is the
induction of anergy, a commonly mentioned example of which (as it is
understood) is the case of ligation of the T cell receptor but not the
appropriate co-stimulatory molecule (i.e., CD28).  Have anergic T cells really
been removed from the pool?  Or, can an anergic T cell be somehow
"re-activated"?  I think the jury is still out on this one, but I'd love to
hear what others think.

Rick Willis
University of Rochester Cancer Center 

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