FUNCTION OF BACTERIAL SUPERANTIGNENS

Thierry Sornasse tsornas at dbmdec5.ulb.ac.be
Wed Feb 23 10:28:23 EST 1994


Hi networkers,

In our laboratory we work on the toxic shock syndrom and more precisely on the
anergy of T cells consecutive to SEB injection.

It is clear that after a burst of activation of the V beta 8 expressing T cells,
these cells become anergic. That means that one or two weeks after injection of
SEB it is impossible to get a good response against the SEB in vitro.

Thus, I think that the superantigens could a way of active supression of the
immune response by inducing the anergy of a sub population of T cells.

Actually, superantigen is not my main subject, thus, I will discuss this question
more precisely with the team that works on this subject.

Best regards

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