FUNCTION OF BACTERIAL SUPERANTIGNENS

Polaris Polaris at exchange.wariat.org
Fri Feb 25 19:47:23 EST 1994


 >   DOES ANYONE HAVE SOME THEORIES AS TO THE VALUE OF BACTERIAL
 > SUPERANTIGENS FOR THE BACTERIA THAT MAKE THEM?  COMPARING THE
 > STRUCTURE-FUNCTION RELATIONSHIPS OF STAPHYLOCOCCAL ENTEROTOXIN B AND
 > TOXIC SHOCK SYNDROME TOXIN-1, IT SEEMS THAT SIMILAR FUNCTIONS ARE
 > PERFORMED BY DIFFERENT SEQUENCES. THIS SUGGESTS THAT T CELL
 > ACTIVATION AND BINDING TO MHC CALLASS II ARE IMPORTANT,
 > AND NOT JUST ACCIDENTS THAT RESULT FROM A PARTICUALAR STRUCTURE.
 >    THERE IS A PLAUSIBLE EXPLANATION FOR VIRAL SUPERANTIGENS, AND THAT
 > IS THAT THE VIRUSES INFECT CELLS THAT ARE IN CYCLE, SO IT IS TO THEIR
 > ADVANTAGE TO STIMULATE MITOSIS.
 >                                             JACK KOMISAR
 >                                             DEXPER at WRAIR-EMH1.ARMY.MIL

Please stop shouting!


--- Origin: The Exchange BBS (216) 261-9911




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