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Oral tolerance (was: immunologists read me)

Shiv A. Prasad shiv at hiv.med.umn.edu
Sat Jan 15 12:33:24 EST 1994

In article <2h7qbv$95i at mserv1.dl.ac.uk> "dLee" <dLee at ccmail.llu.edu> writes:
>A blanket statement that Immunologists are less "computer-minded" than
>other scientists baffles me a little bit.  Considering the nature of
> [...]
>Immunology is still, IMHO, one of the few remaining intrigues in
>science, with all of its unknowns, exceptions, contradictions, etc.,
>and I encourage non-immunologists to continue asking what may seem
>naive questions, if for no other reason than to keep us on our toes.
>But I caution the serious immunologists out there that the naive
>questions which are asked here may belie the numbers of other
>immunologists who are out here listening.
>Dean Lee

There have been a few intellectual strings on this group, unfortunately there 
aren't often more than 4 contributors to a discussion.  Are readers afraid to 
"look stupid" by posting questions and ideas?  That often happens at seminars 
where only a few people question the speaker week in week out. I must confess
to not speaking up as frequently as I should.  Perhaps bionet.immunology is 
just the high- tech question and answer session that follows a seminar, with 
all the inhibitions therein.

A thread like the nose-picking tolerance can get so ridiculous that no-one
takes it seriously.  But it can also be meaningful in discussing oral 
tolerance. So let's talk about that some. 

Oral tolerance is not strictly "tolerance."  The mice/rats do make Ab responses
following the immunization with Ag/CFA.  So what's happening?  Does it upset
the Th1-Th2 balance in favor of Th2's?  A recent paper on oral tolerance in
EA Uveoretinitis (JI 1993. 151(10):5751. shameless plug for my advisor's 
work:-) showed that serum levels of total Ag-specific Ab, IgG1, and IgG2a
weren't greatly different in fed and unfed animals, suggesting that tolerance
was not due to a Th1-Th2 switch.  

Anyone care to respond to this?

Shiv A. Prasad				shiv at lenti.med.umn.edu
Dept. of Microbiology			pras0005 at student.tc.umn.edu
Univ. of Minnesota

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