It is possible though that inhaled antigens do all their tolerising in the gut. Many
parasites that have a lung stage to their life cycle are coughed up and swallowed
and thus end up in the gut (from which they are later spread). Could the same be
true for peptide put up the nose of mice?
Why then is the pulmonary route more efficient than the gut route...how about
synergy between pulmonary tolerance and gut tolerance? How could you
distinguish the two in an experimental system... how about tying off the oesophagus
after admin of the peptide? How do you feed a mouse by drip though?
Dr. Colin R.A. Hewitt
University of Leicester/MRC
Centre for Mechanisms of Human Toxicity
PO Box 138
Phone +44 (0)533 525587
Fax +44 (0)533 525616
E-Mail crah1 at le.ac.uk.