IgG hinge region

James Petts pettsj at visigoth.demon.co.uk
Fri Jan 21 02:33:22 EST 1994

In article <2hme89$m9i at mserv1.dl.ac.uk>, mbwjm at s-crim1.dl.ac.uk (W.J.
Mawby) wrote:

> dear all
>         we are looking at the hinge region of an IgG1 and would like to
> model the structure, unfortunately a search of Brookhaven only gave us strucures
> lacking this region (both Fc and Fab). Is anybody working on this or has any
> information which would be useful to us.

AFAIK, the hinge region is *very* flexible, and no X-ray studies have yet
been puplished. I suspect very strongly that they will be more or less
impossible to obtain, but would *love* to be proved wrong. Modelled
structures (*maybe* from NMR, but otherwise pure modelling) are likely to
be your only bet, I'm afraid.

James Petts
P.S. Please excuse my rottn' english you see moomins go to
school only as long as it amuses them.

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