dfonseca at mail.sas.upenn.edu (Dina Fonseca) asks:
>Are there true peripheral antigens?
>I mean by this, are there proteins expressed and presented in the periphery,
>to which tolerance must be established by peripheral mechanisms? For which
>failure of tolerance induction would lead to autoimmunity?
>Surely such self proteins must exist?
>How could tolerance to such proteins possibly be established?
Proteins that are expressed only after puberty. e.g. sperm proteins in males.
Dr. Colin R.A. Hewitt
University of Leicester/MRC
Centre for Mechanisms of Human Toxicity
PO Box 138
Phone +44 (0)533 525587
Fax +44 (0)533 525616
E-Mail crah1 at le.ac.uk.