Something unknowable in immunology? Simple logic?

Dr. Colin R.A. Hewitt crah1 at leicester.ac.uk
Mon Jan 24 07:22:13 EST 1994


dfonseca at mail.sas.upenn.edu (Dina Fonseca) asks:

>Are there true peripheral antigens?
>I mean by this, are there proteins expressed and presented in the periphery,
>to which tolerance must be established by peripheral mechanisms? For which
>failure of tolerance induction would lead to autoimmunity?
>Surely such self proteins must exist? 
>How could tolerance to such proteins possibly be established?

How about:

Proteins that are expressed only after puberty. e.g. sperm proteins in males.

Dr. Colin R.A. Hewitt
University of Leicester/MRC
Centre for Mechanisms of Human Toxicity
Hodgkin Building
PO Box 138
Lancaster Rd

Phone +44 (0)533 525587
Fax +44 (0)533 525616
E-Mail crah1 at le.ac.uk.

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