T cell co-stimulation/anergy

Dr. Colin R.A. Hewitt crah1 at leicester.ac.uk
Tue Jan 25 06:21:22 EST 1994

Date:          25 Jan 1994 03:14:53 -0000
From:          dexper at wrair-emh1.army.mil
Reply-to:      dexper at wrair-emh1.army.mil
To:            "bionet.immunology mail newsgroup" <bionet-news at daresbury.ac.uk>
Subject:       Re: Something unknowable in immunology? Simple logic?

dexper at wrair-emh1.army.mil writes:

>According to Liu and Janeway (PNAS 89:3845 1992), the antigens
>and the costimulatory molecules must be on the same cell for clonal expansion
>of T cells, which explains why tissues can express autoantigens and contain
>active antigen-presenting cells without inducing autoimmunity. 

Harding et al (Nature, p607, 356, 1992) used plastic coated anti CD3 as an "antigen"
and LPS blasts as providers of costimulation to induce T cell activation. These 
signals are effectively on "different cells", how does this square with the need for the 
two signals on the same cell??

Dr. Colin R.A. Hewitt
University of Leicester/MRC
Centre for Mechanisms of Human Toxicity
Hodgkin Building
PO Box 138
Lancaster Rd

Phone +44 (0)533 525587
Fax +44 (0)533 525616
E-Mail crah1 at le.ac.uk.

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