Anti-Variable Part Antibody?

dLee dLee at ccmail.llu.edu
Wed Jan 26 12:08:58 EST 1994


Philippe Stas writes:

>Does anyone knows if a anti-VH or anti-VL or both exists
>(anti-mouse)?  I would like to know who sells it.

Do you mean against a particular VH region (as defined by a gene
segment) analogous to, say, an antibody to V-beta-8 of the TCR?
It would be nice to know if one existed, although it seems that the
process of affinity maturation would make it less applicable than in
the anti-TCR case.

What about an anti-idiotype?  Since the idiotype has been shown to be
primarily within the VH, sometimes entirely, you could start from
there.


*********************************************************************
Dean Lee                        * We dance 'round in a ring         *
Dept of Micro and Mol Genetics  * and suppose,                      *
Loma Linda University           * But the secret sits in the middle *
dLee at ccmail.llu.edu             * and knows.               R. Frost *
*********************************************************************



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