immunologists read me

Lee Wetzler lwetzler at bu.edu
Thu Jan 27 09:44:15 EST 1994


dLee (dLee at ccmail.llu.edu) wrote:

: Jane Harper writes:

: > I'd love to hear what the folks in this newsgroup
: > feel are the pivotal discoveries that have occurred _outside_ HIV
: > research have been for, say the past 15 years.
: >
: > Any takers?


: I would list the following as an "Immunology Top Ten":
:    (IMHO, of course)

:  in no particular order,

: 1)  "The Groove"- MHC structure and peptide binding site
: 2)  The Immunoglobulin superfamily as a general structural model
:          for receptors
: 3)  Structure of the T-cell receptor (and associated CD3)
: 4)  Gene rearrangment as the mechanism for generation of diversity
: 5)  Mechanism of Superantigens
: 6)  Role of Cell Adhesion Molecules in leucocyte extravasation
: 7)  Signal transduction models for B and T cells (Ca++, IP3, tyr-p)
:       and related identification of many tumor genes (myc, fyn, etc)
: 8)  NF-kappaB/AP-1 and other related molecules in
:       transcriptional regulation
: 9)  Deletion of self-reactive TCR in the thymus as the mechanism
:       for central tolerance
: 10) Positive selection as the mechanism behind MHC-restriction

I would also include the importance of T lymphocyte costimulation
(and lack of it causing T cell tolerance).
 What do others feel?

 ______________________________________  _________________________________
[    Lee Wetzler                       ||                                 ]
[    The Maxwell Finland Laboratory    ||   e-mail  lwetzler at acs.bu.edu   ]
[        for Infectious Diseases       ||                                 ]
[    Boston City Hospital              ||   phone   617-534-4394          ]
[    Boston University                 ||                                 ]
[      School of Medicine              ||   fax     617-534-5280 or 4391  ]
[    774 Albany Street                 ||                                 ]
[    Boston, MA  02118     USA         ||                                 ]
[______________________________________||_________________________________]



More information about the Immuno mailing list