immunologists read me

Santhat Lekhavadthanajai - SCMI - 3636187 gscslh at mucc.mahidol.ac.th
Sat Jan 29 00:13:46 EST 1994



On 27 Jan 1994, Lee Wetzler wrote:

> dLee (dLee at ccmail.llu.edu) wrote:
> 
> : Jane Harper writes:
> 
> : > I'd love to hear what the folks in this newsgroup
> : > feel are the pivotal discoveries that have occurred _outside_ HIV
> : > research have been for, say the past 15 years.
> : >
> : > Any takers?
> 
> 
> : I would list the following as an "Immunology Top Ten":
> :    (IMHO, of course)
> 
> :  in no particular order,
> 
> : 1)  "The Groove"- MHC structure and peptide binding site
> : 2)  The Immunoglobulin superfamily as a general structural model
> :          for receptors
> : 3)  Structure of the T-cell receptor (and associated CD3)
> : 4)  Gene rearrangment as the mechanism for generation of diversity
> : 5)  Mechanism of Superantigens
> : 6)  Role of Cell Adhesion Molecules in leucocyte extravasation
> : 7)  Signal transduction models for B and T cells (Ca++, IP3, tyr-p)
> :       and related identification of many tumor genes (myc, fyn, etc)
> : 8)  NF-kappaB/AP-1 and other related molecules in
> :       transcriptional regulation
> : 9)  Deletion of self-reactive TCR in the thymus as the mechanism
> :       for central tolerance
> : 10) Positive selection as the mechanism behind MHC-restriction
> 
> I would also include the importance of T lymphocyte costimulation
> (and lack of it causing T cell tolerance).
>  What do others feel?
> 
  How about nitric oxide synthase gene expression in activated murine 
macrophage but not in human's?

Santhat Lekhavadhanajai
Dept. of Microbiology, Faculty of Sciences
Mahidol University
Bangkok, Thailand




More information about the Immuno mailing list