immunologists read me
Santhat Lekhavadthanajai - SCMI - 3636187
gscslh at mucc.mahidol.ac.th
Sat Jan 29 00:13:46 EST 1994
On 27 Jan 1994, Lee Wetzler wrote:
> dLee (dLee at ccmail.llu.edu) wrote:
> : Jane Harper writes:
> : > I'd love to hear what the folks in this newsgroup
> : > feel are the pivotal discoveries that have occurred _outside_ HIV
> : > research have been for, say the past 15 years.
> : >
> : > Any takers?
> : I would list the following as an "Immunology Top Ten":
> : (IMHO, of course)
> : in no particular order,
> : 1) "The Groove"- MHC structure and peptide binding site
> : 2) The Immunoglobulin superfamily as a general structural model
> : for receptors
> : 3) Structure of the T-cell receptor (and associated CD3)
> : 4) Gene rearrangment as the mechanism for generation of diversity
> : 5) Mechanism of Superantigens
> : 6) Role of Cell Adhesion Molecules in leucocyte extravasation
> : 7) Signal transduction models for B and T cells (Ca++, IP3, tyr-p)
> : and related identification of many tumor genes (myc, fyn, etc)
> : 8) NF-kappaB/AP-1 and other related molecules in
> : transcriptional regulation
> : 9) Deletion of self-reactive TCR in the thymus as the mechanism
> : for central tolerance
> : 10) Positive selection as the mechanism behind MHC-restriction
> I would also include the importance of T lymphocyte costimulation
> (and lack of it causing T cell tolerance).
> What do others feel?
How about nitric oxide synthase gene expression in activated murine
macrophage but not in human's?
Dept. of Microbiology, Faculty of Sciences
More information about the Immuno