a thought

Ken Frauwirth BioKen frauwirt at mendel.Berkeley.EDU
Sun Jul 17 20:20:52 EST 1994


Along the lines of a "general factor", but still trying to "improve" the
patients own T cells, there is the possibility of using retrovirally
introduced genes to beef up the immune cells.  The advantage to this is that
a retrovirus (mutated to prevent replication, of course) can be targeted to
a specific tissue or cell type.  For example, using a deactivated HIV-like
vector could target a resistance gene (yet to be developed) to CD4+ T cells.
This obviates the need to remove cells from the patient.  In fact, this type
of gene therapy is already in the works for genetic diseases (cystic
fibrosis, for example).

BioKen

-- 
Ken Frauwirth                  _           _
frauwirt at mendel.berkeley.edu  |_) *    |/ (_ |\ |
Dept. of Molec. & Cell Bio.   |_) | () |\ (_ | \|  
Univ. of Cal., Berkeley   .sig made under strict rabbinical supervision



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