a thought

Ken Frauwirth BioKen frauwirt at mendel.Berkeley.EDU
Sun Jul 17 20:20:52 EST 1994

Along the lines of a "general factor", but still trying to "improve" the
patients own T cells, there is the possibility of using retrovirally
introduced genes to beef up the immune cells.  The advantage to this is that
a retrovirus (mutated to prevent replication, of course) can be targeted to
a specific tissue or cell type.  For example, using a deactivated HIV-like
vector could target a resistance gene (yet to be developed) to CD4+ T cells.
This obviates the need to remove cells from the patient.  In fact, this type
of gene therapy is already in the works for genetic diseases (cystic
fibrosis, for example).


Ken Frauwirth                  _           _
frauwirt at mendel.berkeley.edu  |_) *    |/ (_ |\ |
Dept. of Molec. & Cell Bio.   |_) | () |\ (_ | \|  
Univ. of Cal., Berkeley   .sig made under strict rabbinical supervision

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