MHC-II on pluripotent stem cells
Richard R. Hardy
hardy at mighty.fccc.edu
Thu Jul 21 13:41:23 EST 1994
In article <774731353snz at dumpling.demon.co.uk>,
Adrienne at dumpling.demon.co.uk wrote:
> Does anyone know for sure how far back MHC-II is expressed on
> pluripotent stem cells in mice and people? In other words, does the very
> earliest stem cell express Class-II?
In human I believe HLA-DQ goes very far back, possibly as far as stem
cells; the others are not so well characterized. In mouse, class-II is
more restricted, and on B cells is first detectable at the late Pre-B
stage in bone marrow.
Fox Chase Cancer Center
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