MHC-II on pluripotent stem cells

Richard R. Hardy hardy at
Thu Jul 21 13:41:23 EST 1994

In article <774731353snz at>,
Adrienne at wrote:

> Does anyone know for sure how far back MHC-II is expressed on 
> pluripotent stem cells in mice and people?  In other words, does the very
> earliest stem cell express Class-II?
> -- 

In human I believe HLA-DQ goes very far back, possibly as far as stem
cells; the others are not so well characterized.  In mouse, class-II is
more restricted, and on B cells is first detectable at the late Pre-B
stage in bone marrow.

R. Hardy
Member, ICR,
Fox Chase Cancer Center
(215) 728-2463

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