Nude mice: immune defects other than T cells ?

Thierry Sornasse tsornas at dbmdec5.ulb.ac.be
Mon Mar 7 08:36:46 EST 1994

Hi Immunenetters,

I study the possible influence of T cells on the maturation of DC. Since Nude
mice have a little number of fonctionnal T cells, I work with type of mice.
Although, I am wondering if the Nude mutation has other affects on other cells
type of the immune system.

I know that some authors suggest that B cells of Nu/Nu mice are not normal but is
there any evidence for that ?
I would like also to know if other cell types like monocytes/macrophages,
granulocytes, NK cells, mastocytes are affected by the Nu mutation ?

Thank you in advance for your help


/              T H I E R R Y              S O R N A S S E
/                  Laboratoire de Physiologie Animale 
/      Universite Libre de Bruxelles / Free University of Brussels
/              Rue des Chevaux, 67.   1640  Rhode-St-Genese 
/                              B E L G I U M
/  Phone: 32.2.6509850                               Fax: 32.2.6509840
/                        tsornas at dbmdec5.ulb.ac.be


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