Human IgA

Jesus del Valle del_valle at MPIMG-Berlin-Dahlem.MPG.DE
Fri Mar 11 13:44:24 EST 1994


Hi. I am currently studying the IgA protease of the pathogenic bacterium 
Neisseria meningitidis. It is known to cleave only human IgA1 and primates 
IgA therefore I am interested in the following questions: Since they only 
differ in 20 of the approx. 330 aa comprising the alpha chain, is there a 
functional difference between both human IgAs (IgA1 and IgA2)?. Do cells 
expressing them are somehow different or react to different interleukins or 
anything else?. Do other primates or animals have also two or more IgAs?. 
Any comments or literature references will be appreciated. Thanks a lot.
Jesus del Valle    



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