Question on conjugate stability

Jeffrey Vassallo vassallo at delphi.com
Fri Mar 25 18:21:51 EST 1994


	I am having a problem with stabilizing a conjugate for Toxin A, C.
difficile.  When placed at 37 degrees for one week the activity decreases
40% and a precipitate forms.  The precipitate formed was suggested to be
calcium triphosphate and mercury sulfide for the white and black precipitate
respectively by Hyclone.  Apparently a reaction is occuring withing the
buffer which is destabilizing the conjugate.  If any one can offer me some
suggestions please send them in e-mail.  It would be greatly appreciated.
					Thank you,
						Jeff Vassallo



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