IUBio

immune transplant for treating hiv or organ rejection

Mike Klopfer klopfer at natinst.com
Mon May 9 23:12:23 EST 1994


I read somewhere about transplanting a functioning human immune system
into SCID mice. I was wondering if there are other examples of transplanting
immune systems between species. I was wondering if this could be a potential
treatment for hiv e.g. using the immune sytem of a species that isn't 
susceptible to the virus to replace the immune system of the hiv infected
person.

Along this line I've heard of a treatment (maybe it was called Total
Lymphoid Irradiation) using radiation to destroy a persons immune
system. Then the immune system can be restarted from saved stem cells
possibly eliminating rejection of transplanted organs. I was wondering
if something like this is being tried or used? If this is not successfull I 
would also be interested in finding out what is the best guess as to why not.

Thanks for your time.

mike




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