IUBio

cross reactivity and homology

Deborah Hodges Rheumatol dh124 at mole.bio.cam.ac.uk
Thu May 26 10:21:21 EST 1994


	Hi, I'm sorry if this is a really  basic question (probably been
asked umpteen times already). My lab has a polyclonal antibody that is showing
an unexpected cross reactivity. 
	I've lined up the sequencences using a comparison program (sip in 
the Staden package) and there are 3 stretches of five homologous residues and
one of ten with a few breaks in it. Would any of these be sufficient to 
cause the cross reactivity given that both stretches are probably in helical 
regions?
	Thanks in advance
		Debbie
-- 
-------------------------------- ---------------------------------------     
Debbie Hodges			|  Well lookee here - I've got a 
dh124 at mole.bio.cam.ac.uk	|  brand new sig.
E6 Addenbrookes Cambridge UK	|	              :)



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