Chimeric receptor choice

Sue Jeffrey sjeffrey at mskcc.org
Wed Nov 2 15:06:34 EST 1994


I'm trying to construct a chimeric receptor and I would like input on a
suitable extracellular portion. I would like it to be as small as possible,
since the vector I am using has a size constraint (it should be about 1-1.5
kb max for the extracellular portion). Other criteria: it should only be
present on specialized cells, and have commercially available ligand and
antibody. Originally I was using the cFMS receptor (CSF-1 receptor) but it
is too large. Any advice would be appreciated.

Sue Jeffrey
Memorial Sloan-Kettering Cancer Center
New York City
email: sjeffrey at ski.mskcc.org



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