Q: CD8+ T cell lines

psycler at netcom.com psycler at netcom.com
Mon Nov 7 22:24:31 EST 1994


Zafer Yildirim (zxy5 at po.CWRU.Edu) wrote:

: I just wanted to get your ideas about a question I have no answer
: All T cell lines ( other than T cell clones which are not of 
: tumor origin ) are CD4+. I have never seen a CD8+ tumor cell line
: and I have been wondering why? Any comments?

I believe that CD8+ cells are dependent on interleukin-2 which
they obtain from production by CD4+ cells.  Why the addition
of exogenous IL-2 is not sufficient, I'm not sure.  Offhand, I
might suspect the involvement of other CD4+ cytokines.
-- 
          Psycler  @T@~                                      



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