Monoclonals for flu HA (mt sinai strain)

Antibody antibody at bii.ch
Thu Nov 10 13:25:04 EST 1994


Why dont you ask Walter Gerhard. He has lots of monoclonals to HA.
With Medline you should anyhow be able to find papers of him regarding
mAbs specific for known determinants on HA.

Regarding the full sequnce of PR/8/34, arent you able to use GCG with
your known Canton reference (just pick a piece of it) and "fasta"?
One of the references you do find (if not to lazy) is Winter, Fields
and Brownlee. Just a hint: if you use the peptide sequence "FERFEIFPK"
for searching with GCG you will be able to find lots of HAs of different
strains, including the one you need.

Good luck
    jorg




In article <39mkin$rl6 at dingo.cc.uq.oz.au>, forrest at biosci.uq.oz.au (acer) wrote:

>  I put this in bionet.virology but thought you might be able to help too.
> 
> G'day all,
>         I'm enquiring for someone in my lab who doesn't have net access.
> 
> She's looking for anyone who might have monoclonals against each of the
> antigenic sites of influenza/PR/8/34 (Mt Sinai). She's after both linear
> and non-linear epitopes.
> 
> She's also wondering whether anyone has the entire sequence for the mt sinai
> HA, she only has the partial sequence from Caton et al. (1982;cell).
> 
> But wait there's more!!!
>         Does anyone have any info on the cross reactivity between Mt Sinai
> and cambridge strains (presumably the mabs).
> 
> Thanks in advance for any info you can send me (and her), if you can
> supply appropriate Mabs then she'll contact you direct through formal
> channels (probably fax).
> 
> Alistair Forrest (PhD student)



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