Question on names of immunoglobins

Martti Tolvanen tolvanen at cc.Helsinki.FI
Thu Nov 10 08:11:34 EST 1994


In <1994Nov9.155909.1 at cc.newcastle.edu.au> mdcabl at cc.newcastle.edu.au writes:

>Also, how did we get the silly
>nomenclature for pepsin digests of IgG.  F(ab')2 looks like a calculus problem.
>I think F= fragment and ab=antigen binding but what's the prime symbol for?

The prime is there (I think) just for showing that the fragment is slightly
different from the papain fragment F(ab), ie. it includes the cysteine 
that forms the heavy-heavy disulfide.
-- 
Martti.Tolvanen at helsinki.fi Dept. Biochem. Univ. Helsinki, Finland
For more info: finger tolvanen at kruuna.helsinki.fi



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