Antibody production without B cells.

mahmoud dbell at julian.uwo.ca
Tue Nov 29 22:41:44 EST 1994


In article <3bgh5n$ol2 at newsbf01.news.aol.com> dpigg at aol.com (DPIGG) writes:
>From: dpigg at aol.com (DPIGG)
>Subject: Antibody production without B cells.
>Date: 29 Nov 1994 19:31:51 -0500

>My question is if someone can lead me to a review article,   or an
>ariticle about this subject?  Is it possible to take out the gene for
>anibody information and express that in bacteria or other micro-organism?


The answer is yes. Here are two review articles which might help:

Hoogenboom HR & Winter G. (1992) By-passing immunisation. Human
antibodies from synthetic repertoires of germline VH gene segments 
rearranged in vitro.  J Mol Biol  227:381-388.

Winter G, Griffiths AD, Hawkins RE & Hoogenboom HR. (1994) Making 
antibodies by phage display technology.  Annu Rev Immunol  12:433-455.


mahmoud



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