Antibody production without B cells. (fwd)
haoxiao at cc.UManitoba.CA
Wed Nov 30 00:02:06 EST 1994
> From BIOSCI-REQUEST at net.bio.net Tue Nov 29 19:20:18 1994
> To: immunology at net.bio.net
> From: dpigg at aol.com (DPIGG)
> Subject: Antibody production without B cells.
> Date: 29 Nov 1994 19:31:51 -0500
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> My question is if someone can lead me to a review article, or an
> ariticle about this subject? Is it possible to take out the gene for
> anibody information and express that in bacteria or other micro-organism?
Yes, check MEDLINE for recombinant Ab. gene coded for specific Ab can be
isolated either from hybridoma of Bcell or just Bcell.
Or you can produce Ab-like protein using gene coded for antigen-receptor from
macrophages and Tcell (isolated by solid phase-affinity traping) without
immunizing the animal.
More information about the Immuno