Antibody production without B cells. (fwd)

Hao Xiao haoxiao at cc.UManitoba.CA
Wed Nov 30 00:02:06 EST 1994


DPIGG writes:
> From BIOSCI-REQUEST at net.bio.net Tue Nov 29 19:20:18 1994
> To: immunology at net.bio.net
> From: dpigg at aol.com (DPIGG)
> Subject: Antibody production without B cells.
> Date: 29 Nov 1994 19:31:51 -0500
> Sender: news at newsbf01.news.aol.com
> Message-ID: <3bgh5n$ol2 at newsbf01.news.aol.com>
> NNTP-Posting-Host: newsbf01.news.aol.com
> 
> My question is if someone can lead me to a review article,   or an
> ariticle about this subject?  Is it possible to take out the gene for
> anibody information and express that in bacteria or other micro-organism?
> 
> 

Yes, check MEDLINE for recombinant Ab. gene coded for specific Ab can be 
isolated either from hybridoma of Bcell or just Bcell.
Or you can produce Ab-like protein using gene coded for antigen-receptor from
macrophages and Tcell (isolated by solid phase-affinity traping) without 
immunizing the animal.



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