question/autoreactive Tcells

John Barton jjb at watson.ibm.com
Mon Oct 3 08:14:11 EST 1994


In article <psyclerCwxFK1.Jr at netcom.com>, psycler at netcom.com writes:
|> Normal individuals are considered immunologically tolerant to self
|> antigens. Examples of autoreactive immunity are multiple sclerosis,
|> lupus, diabetes melitus, and rheumatoid arthritis.  In the case of diabetes
|> for example, the autoreactive T cells recognize antigens found in
|> islet cells of the pancreas and the cascade of events following this
|> recognition throws off the ability of these cells to produce
|> insulin.  Hence, disease.
|> 

  In the corresponding scenario for lupus, the (false) antigen is
often listed as DNA.  Is it normal for cells to present bits of 
their own DNA?  Maybe its more correctly RNA?  What else is known
about the antigen for lupus (one of the oddest of these odd 
afflictions)?

-- 
John.

John J. Barton        jjb at watson.ibm.com            (914)784-6645
H1-C13 IBM Watson Research Center P.O. Box 704 Hawthorne NY 10598



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