greatest immunology discoveries

Michelle Epstein mepstein at
Thu Oct 27 09:15:28 EST 1994

I think that the greatest discovery in the last 25 years in immunology 
has to be monoclonal antibodies. It may not be as elegant and 
theoretically based but is one of the most important discoveries for 
immunology and many other biological disciplines.

On 26 Oct 1994, Ephraim Fuchs wrote:

> I would like to know what people think is the greatest advance in 
> immunology in the last 25 years.  My opinion is that it is the two signal 
> model of lymphocyte activation, first proposed by David Dresser, then Don 
> Forsdyke (if I'm not mistaken, he is the founder of this usenet group), 
> then championed by Peter Bretscher and Mel Cohn and, for T cells, by 
> Kevin Lafferty and Alistair Cunningham.  A distant second would be the 
> discovery of MHC restriction of T cell responses by Peter Doherty and 
> Rolf Zinkernagel.

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