greatest immunology discoveries

Ephraim Fuchs ejf at
Wed Oct 26 16:27:37 EST 1994

I would like to know what people think is the greatest advance in 
immunology in the last 25 years.  My opinion is that it is the two signal 
model of lymphocyte activation, first proposed by David Dresser, then Don 
Forsdyke (if I'm not mistaken, he is the founder of this usenet group), 
then championed by Peter Bretscher and Mel Cohn and, for T cells, by 
Kevin Lafferty and Alistair Cunningham.  A distant second would be the 
discovery of MHC restriction of T cell responses by Peter Doherty and 
Rolf Zinkernagel.

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