greatest immunology discoveries

Ken Hoekstra hoekstra at
Mon Oct 31 22:04:04 EST 1994

Michelle Epstein (mepstein at wrote:

: I think that the greatest discovery in the last 25 years in immunology 
: has to be monoclonal antibodies. It may not be as elegant and 
: theoretically based but is one of the most important discoveries for 
: immunology and many other biological disciplines.

: On 26 Oct 1994, Ephraim Fuchs wrote:

: > I would like to know what people think is the greatest advance in 
: > immunology in the last 25 years.  My opinion is that it is the two signal 
: > model of lymphocyte activation, first proposed by David Dresser, then Don 
: > Forsdyke (if I'm not mistaken, he is the founder of this usenet group), 
: > then championed by Peter Bretscher and Mel Cohn and, for T cells, by 
: > Kevin Lafferty and Alistair Cunningham.  A distant second would be the 
: > discovery of MHC restriction of T cell responses by Peter Doherty and 
: > Rolf Zinkernagel.
: > 
: > 
: > 
: > 

The discovery and research into how MHC works is one of the most 
interesting topics in immunology today if not one of the greatest 
achievements. (by many of course).

* Ken Hoekstra (veterinary technician) B.Sc  hoekstra at    *
* University of British Columbia             Ken.Hoekstra at*

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