Th1 and Th2 separation?

JAF at UNCVX1.OIT.UNC.EDU JAF at UNCVX1.OIT.UNC.EDU
Wed Sep 7 09:39:22 EST 1994


I think that the data is pretty clear, Tim Mossman not withstanding, that 
Th1 qnd Th2 cytokine production patterns are characteristics of a 
population response and not a cell in vivo.  In situ hybriddization 
studies on clones of T cells show a variable pattern of transcription of 
cytokine genes, including those which are of the incorrect type.  Don't 
overinterpret the data.  The idea of different cytokine response patterns 
influeincg the outcome of an infection is very different fromt the 
exixitence of descrete cell populations.
Jeff Frelinger




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